In addition, you should use effective birth control while youre taking Prolia. So, dont be afraid to ask questions or offer feedback on your treatment. Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. For more information on this side effect, see Side effect specifics below. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Please see Prolia full (Biosimilars are like generic drugs. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. 1 shot every 6 months could mean fewer doses. Find out why people need calcium, which foods provide it, and what happens if they consume. A biologic drug is made from parts of living organisms. Tell your doctor right away if you become pregnant while taking Prolia. Constipation was also reported as a side effect in females using Prolia for osteoporosis. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. Its given to adults who are at high risk for bone fractures. So, your bones become weak and brittle. Ask your plan if they cover the drug, and what the cost will be for you. Prolia can also cause bones to not form correctly and reduced growth in a fetus. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Its important to discuss all your concerns with your doctor. See what this means for you in the chart below. These problems may include: Your risk for mouth-related side effects may be higher if you have problems with your teeth. Prolia can cause certain side effects, some of which are more common than others. But weight gain may be a symptom of a side effect called peripheral edema. But its believed that these side effects are rare. You might wonder how Prolia and the drug Xgeva compare. Calcium and Vitamin D: Important Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. You It could harm the unborn baby or cause birth defects. Below, we answer some common questions about taking Prolia. If you receive Prolia, you should not receive XGEVA. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. (Chlorhexidine helps kill germs in your mouth.). Do not shake the prefilled syringe. Youll receive Prolia doses from a healthcare professional. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. You may have questions about Prolia and your treatment plan. What osteoporosis medications are there, and what side effects do they have? Nonmetastatic means the cancer hasnt spread to other areas of the body. Prolia isnt approved to treat osteopenia or arthritis. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. Because Prolia can also cause low blood calcium, your risk may increase if you receive Prolia. No one in clinical trials of Prolia had to stop taking the drug due to dizziness. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. Prolia may be used off-label for RA, if you have a high risk for bone fractures. The study uses data from the FDA. These are serious. Thyroid or parathyroid surgery. This makes your bones weak and increases your risk for bone fractures or breaks. Before your appointment, write down questions, such as: How will Prolia affect my body, mood, or lifestyle? If you drink alcohol, talk with your doctor about how much is safe to drink with your condition. If your dizziness doesnt go away or becomes severe, talk with your doctor. The conditions and factors to consider include: Upcoming dental procedures. Osteoporosis Medications (Bisphosphonates) - Johns Hopkins But nausea may be a symptom of side effects such as vertigo or constipation. Ask your doctor about the pros and cons of using Prolia. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. But its not clear whether this side effect occurred in clinical studies. If you have low calcium levels, you should not take Prolia. Sciatica is described as a shooting pain that travels from the lower back down a leg. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. To help prevent low calcium, your healthcare provider may also Use of the terms female and male in this article refers to sex assigned at birth. These side effects may be temporary, lasting a few days or weeks. 8,432 people who take Prolia and Calcium together, and have interactions are studied. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. If youre concerned about tingling while using Prolia, talk with your doctor. And be sure to let your doctor know about all the medications youre currently taking. Others may continue for as long as you take the drug, but they can be easily managed. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. generic drugs) are not considered. Common side effects of this osteoporosis treatment injection include muscle, joint, and back pain. The lists below describe some of the more common side effects that Prolia may cause. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. Adults over age 50 should not exceed 2,000 mg total per day. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. Be sure to read this information carefully each time. Osteoporosis treatment: Medications can help - Mayo Clinic Talk with your doctor or health care professional about your birth control options while taking this medicine. Doing so will help to prevent dental problems. Learn about the different options, including the benefits of each and any potential side, A FRAX score can help predict the risk of fractures in people with osteoporosis. And ask your doctor about which drug is right for your condition. The most common medications prescribed to lower cholesterol are statins. Q: Does AlgaePlus Increase Bone Mass? You should not receive Prolia if you are allergic to denosumab, or if you For instance: Both Prolia and Forteo are given as injections under your skin. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments Brush and floss your teeth regularly while receiving this medication. may occur. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). Your doctor can also advise you on symptoms of low calcium to look for. You should also talk with your doctor if you have nausea during treatment. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. This was one of the most common side effects in clinical trials of females who received Prolia for osteoporosis after menopause. Continue reading, Prolia (denosumab) does increase bone density. Talk with your doctor about the best options for treating your condition. And you should continue using birth control for at least 5 months after stopping Prolia. Your doctor or health care professional may order blood tests and other tests to see how you are doing. Prolia works by targeting a molecule called RANKL that osteoclasts need to work. 2023 Healthline Media UK Ltd, Brighton, UK. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. WebDrug interactions are reported among people who take Prolia and Calcium. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. Calcium Supplements: Should You Take Them? - Johns Hopkins Musculoskeletal pain from Prolia is mild or manageable for most people. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Heres some information on pregnancy, breastfeeding, and Prolia use. Stopping Prolia doesnt cause withdrawal symptoms. They will also explain how much youll be given and how often. They may want to check for other causes. What should be considered before taking Prolia? This medication guide provides information about the Prolia brand of denosumab. Be sure to talk with your doctor about your health history before you take Prolia. Prolia can cause both mild and serious side effects. You may also want to do some research on your own. Results may vary. Prolia also has other uses, which are described in the next section below. Throw away a prefilled syringe after one use, even if there is still medicine left inside. DENOSUMAB (den oh sue mab) slows bone breakdown. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. Do not stop using this medicine without first talking to your doctor. you can take. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. Prolia can also cause low calcium levels. Low blood calcium level. Heres a sample meal plan thats packed with nutritious foods just for. A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. Do not become pregnant while taking this medicine or for 5 months after stopping it. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements). This is because the drug may be harmful to a growing fetus. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. These types of medications come in forms that are taken by mouth and forms that are given by injection. Osteoporosis If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. And they want you to get the best care possible. But hair loss has been reported by people who have taken Prolia since then. Some people have developed unusual fractures in their thigh bone. Denosumab is contraindicated in women with hypocalcaemia. Prolia Subcutaneous: Uses, Side Effects, Interactions, Pictures Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. for prostate cancer that has not spread to other parts of the body. Costs of prescription drugs can vary depending on many factors. Prolia should not be used during pregnancy. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. You are encouraged to report negative side effects of prescription drugs to the FDA. Calcium has active ingredients of calcium. Prolia contains the same medicine as XGEVA (denosumab). In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. Ask your doctor about your own risk. Talk with your doctor about your health history and discuss your risks with Prolia treatment. Calcium and calcium supplements: Achieving the right Call your doctor or health care professional if you are unable to keep an appointment. Some people may have dental or jaw-related issues with Prolia use. You may need to go to the hospital for treatment. Take good care of your teeth and gums while you receive Prolia. Copyright 2023 Elsevier Inc. All Rights Reserved. Prolia Injection (Denosumab): Uses & Side Effects Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. This could include having: Before taking Prolia, share your dental history with your doctor. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Keep out of the reach of children and pets. It is important to check supplement labels to ensure that the product meets United States Pharmacopeia (USP) standards. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). They can help answer any questions you have about side effects from taking the drug. Learn strategies you can use today. The list below may not include all possible serious side effects of the drug. For information about the difference between sex and gender, see this article. If you have any questions about Prolias side effects, talk with your doctor. However, drinking too much alcohol may raise your risk of falling. They can suggest ways to help relieve these side effects. It is important not to miss your dose. Call your doctor for medical advice about side effects. Special care may be needed. When estrogen levels drop, your risk of osteoporosis goes up. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Vitamin D The body needs vitamin D to absorb calcium. Talk with your doctor if youd like to know about taking generic denosumab. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture. (2021). Your doctor may also recommend other treatments with Prolia to help increase your bone mass. Check with your doctor if you have more questions about these drugs. (Biologic medications are made from living organisms.). But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. So, if you want to stop taking Prolia, talk with your doctor. Every 6 months youll get another dose of Prolia. Be sure to talk with your doctor about which medication is right for you. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. This may help to protect healthy cells from damage. An allergic reaction is possible after using Prolia. Here are some frequently asked questions about the drugs side effects and their answers. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Take only the amount of calcium and vitamin D that your doctor has prescribed. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Your risk for some health conditions increases when you are postmenopausal. These include osteonecrosis of the jawbone. Also describe any vitamins, herbs, or supplements you use. WebMost people can get adequate calcium through their diet if they make an effort. Women Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. Learn more about some of the side effects Prolia may cause. Also tell them if you smoke, drink alcohol, or use illegal drugs. The drug stays in your system and continues to slow bone breakdown over this period of time. Last updated on Feb 8, 2023. All rights reserved. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. Specifically, Prolia works by blocking a protein called RANK. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. People need calcium for bone health and other functions. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. You might be interested in seeing how Prolia and the drug Boniva compare. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. Youll likely have questions about your condition and treatment choices. Before you have any dental work done, tell your dentist you are receiving this medicine. Tingling wasnt specifically reported as a side effect of Prolia in clinical trials. Patients in the study may take other drugs besides Prolia and Calcium. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. And if you have osteoporosis, falling could increase your risk of fractures. Before you start Prolia treatment, your doctor will examine the inside of your mouth. Can diet help improve depression symptoms? People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. It may also be higher if you have dental work done while youre taking Prolia. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. In addition to treating osteoporosis, which is described just above, Prolia also has other uses. Nausea can sometimes be a symptom of severe constipation. It is often used in osteoporosis. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. You can also visit the Prolia manufacturers website to see if they have support options. Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. Amount of calcium needed when taking Prolia The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Kidney problems. But if you think youre having a medical emergency, call 911 or your local emergency number. Prolia comes as a solution thats given as an injection under your skin. If youre pregnant or breastfeeding, or considering either, talk with your doctor. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. My GP (not the doctor who treats my osteoporosis) wondered if my early complete hysterectomy (I havent taken estrace in 15 years) and high dosage of thyroid I must take daily, effect the absorption of calcium? Drug class: Miscellaneous bone resorption inhibitors. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). Having a tooth extraction while youre using Prolia may increase your risk for these side effects. If your Prolia treatment is stopped, talk to your doctor about other medicine that Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Use of the terms female and male in this article refers to sex assigned at birth. If you have a low calcium level, you should not take Prolia. These effects are called interactions. Breastfeeding. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Weakness and tingling can also occur. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. They may also have you see your dentist. Coral calcium is also used in maxillofacial surgery and bone grafting. Its possible that some of Prolias side effects may be long term, but theyre rare. Prolia (Injection) Uses, Dosage & Side Effects - Drugs.com If you are a healthcare professional, click "I Agree" to continue. You do not give Prolia to yourself. Do not use denosumab if you are pregnant. Last medically reviewed on November 29, 2022. The drug could cause your calcium level to drop too low. Prolia is a medicine that may affect the ability of your body to fight infections. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. * In this article, we use the terms male and female to refer to someones sex assigned at birth. No, weight gain wasnt reported as a side effect of Prolia in clinical trials. Use of the term male in this article refers to sex assigned at birth. Find out which foods can help. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. Most side effects from Prolia are mild and can go away on their own within a few days or weeks. You should always consult your doctor or another healthcare professional before taking any medication. We do not endorse non-Cleveland Clinic products or services. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia.